For adults who want their omega-3 focused where the cardiovascular evidence is strongest — on purified EPA.
Interested to learn more. Contact us at info@nikkopharma.co.jp

Omega-3
When choosing an omega-3, don’t only ask how much you’re getting. Ask what omega-3 you’re getting.
Extensively studied and proven in major cardiovascular outcome trials.
Has important nutritional roles, particularly in the brain and eyes.
Formulation
More isn’t always better.
More types of omega-3 do not automatically mean greater cardiovascular benefit. Major cardiovascular outcome studies using purified EPA have demonstrated significant cardiovascular event reduction.
A CLEARER FOCUS FOR A HEALTHIER HEART
Softgel
More EPA in a more compact softgel.
Who it is for
PURO Ikosa-EPA is designed for adults seeking a more focused omega-3 approach for heart health.
Heart health is your main priority
You prefer a highly purified, EPA-focused omega-3
You are managing cholesterol and cardiovascular disease, including with statins or other lipid-lowering medicines, and want to discuss EPA supplementation with your doctor or pharmacist.
When your priority is the heart, keep the focus on EPA.




























Heart check
Answer 7 quick questions about your heart health. It takes about a minute, and your answers stay on your device.
Quality
Developed to Nikko Pharma’s Japanese quality standards, with a strong emphasis on stringent quality control and manufacturing consistency.
Manufactured under stringent GMP quality control in New Zealand.
Halal certified
Evidence
Two landmark trials. A clearer direction for heart health.
18,645
patients
EPA added to statin therapy was associated with a 19% relative reduction in major coronary events versus statin therapy alone in the population studied.1
8,179
patients
In statin-treated, high-risk patients with elevated triglycerides, icosapent ethyl was associated with a 25% relative reduction in the primary cardiovascular composite endpoint versus placebo.2
Want to understand why?
Explore the EPA scienceClinical studies referenced here evaluated specific EPA formulations, doses and patient populations and should not be interpreted as clinical trials of PURO Ikosa-EPA itself.
1. Yokoyama Mitsuhiro, Origasa Hideki, Matsuzaki Masunori, Matsuzawa Yuji, Saito Yasushi, Ishikawa Yuichi, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369(9567):1090-1098. doi:10.1016/S0140-6736(07)60527-3
2. Bhatt Deepak L, Steg P Gabriel, Miller Michael, Brinton Eliot A, Jacobson Terry A, Ketchum Steven B, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22. doi:10.1056/NEJMoa1812792
FAQ
Most conventional omega-3 products contain a combination of EPA and DHA. PURO Ikosa-EPA is specifically focused on EPA, with DHA removed through further refinement.
Each softgel provides 489 mg EPA Ethyl Ester, giving Ikosa a higher EPA concentration in a compact softgel.
More importantly, purified EPA has the strongest cardiovascular outcomes evidence among omega-3 formulations studied in major clinical trials.
More isn’t always better.
Ikosa removes DHA through further refinement to keep the formulation focused on EPA. This approach follows the cardiovascular clinical evidence, where significant cardiovascular benefit has been demonstrated with purified EPA without DHA.
DHA removed by choice. Focused on EPA.
Not necessarily. More types of omega-3 do not automatically mean more cardiovascular benefit.
Major cardiovascular outcomes studies using purified EPA have demonstrated significant cardiovascular event reduction, while major studies using combined EPA + DHA have not consistently demonstrated the same benefit.
For heart health, purified EPA has the strongest cardiovascular outcomes evidence among omega-3 formulations studied.
That is why PURO Ikosa-EPA keeps the focus on EPA.
EPA concentration refers to how much of the oil inside the softgel is actually EPA.
Each Ikosa softgel provides 489 mg EPA Ethyl Ester from 555.56 mg of fish oil. Its higher EPA concentration allows Ikosa to provide a focused amount of EPA in a more compact softgel.
Smaller softgel. Higher EPA concentration.
PURO Ikosa-EPA is for adults whose main priority is heart health and who want their omega-3 intake to focus specifically on EPA.
Conventional EPA + DHA omega-3 products are generally positioned for broader nutritional support, including the nutritional roles of DHA for areas such as the brain and eyes.
Ikosa has a more specific purpose: when your priority is the heart, keep the focus on EPA.
Take either 2 softgels once daily, or 2 softgels twice daily.
Each softgel provides 489 mg EPA Ethyl Ester.
If you have an existing medical condition or are taking prescription medicines, follow the advice of your doctor or pharmacist.
We generally do not recommend adding another omega-3 product, particularly one containing DHA, when your purpose is heart health.
The cardiovascular outcomes evidence supporting purified EPA comes from EPA-focused formulations without DHA. If you add an EPA + DHA fish oil, the resulting combination is no longer the same formulation studied in those cardiovascular outcomes trials.
If you are already taking another omega-3 product, speak with your doctor or pharmacist before combining it with Ikosa.
Yes. Heart health is a long-term commitment, and Ikosa is intended for regular daily use.
The major cardiovascular studies supporting purified EPA followed patients for several years, rather than using EPA only for a short period.
For ongoing heart-health support, consistency matters more than short-term use.
If you are under medical treatment, continue to review your supplements with your doctor or pharmacist.
Fishy aftertaste can occur with fish-oil products, but Ikosa uses a highly concentrated EPA formulation in a smaller softgel, meaning less total oil needs to be consumed compared with some conventional lower-concentration fish-oil formulations.
For this reason, fishy aftertaste may be less noticeable for some people.
However, taking several softgels together — for example, 4 softgels at one time — may increase the chance of a slight fishy aftertaste or burp. Taking Ikosa according to the recommended dosing schedule rather than taking all softgels together may help.
PURO Ikosa-EPA as a finished product is not separately IFOS certified.
However, the omega-3 raw material used to manufacture Ikosa is IFOS certified, providing independent quality testing of the omega-3 ingredient used in the product.
Contact
Know what you’re taking. Know why you’re taking it.
PURO Ikosa-EPA — Purified EPA. Cardiovascular-Focused by Design.
Heart check
This heart check is for general education only. It does not diagnose any condition or calculate your actual cardiovascular risk, and it does not replace advice from a doctor or pharmacist. PURO Ikosa-EPA is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.