PURO Ikosa-EPA 489mg Purified EPA.Cardiovascular-Focusedby Design.

For adults who want their omega-3 focused where the cardiovascular evidence is strongest — on purified EPA.

Explore the EPA science

Interested to learn more. Contact us at info@nikkopharma.co.jp

A clear PURO Ikosa-EPA softgel
  • 01489 mg EPAper softgel
  • 02EPA-focusedfor heart health
  • 03Compact & Easysoftgel

Omega-3

One ‘Omega-3’ label. Different omega-3s.

When choosing an omega-3, don’t only ask how much you’re getting. Ask what omega-3 you’re getting.

EPA

Extensively studied and proven in major cardiovascular outcome trials.

DHA

Has important nutritional roles, particularly in the brain and eyes.

Formulation

Pure EPA. Purposefully focused.

More isn’t always better.

More types of omega-3 do not automatically mean greater cardiovascular benefit. Major cardiovascular outcome studies using purified EPA have demonstrated significant cardiovascular event reduction.

  • Purified EPA without DHA
  • Strong cardiovascular benefit outcome demonstrated in large human clinical trials
A clear glass heart glowing softly from within

A CLEARER FOCUS FOR A HEALTHIER HEART

Softgel

Concentrated EPA. Compact softgel.

More EPA in a more compact softgel.

PURO Ikosa-EPA

A clear PURO Ikosa-EPA softgel
489 mg EPA Ethyl Ester
555.6 mg oil
EPA
(~90%)

Conventional Omega-3

A larger golden conventional fish oil softgel
180 mg EPA + 120 mg DHA fish oil
1000 mg oil
Inactive remainder
(~70%)
EPA+DHA
(~30%)

Who it is for

Who is PURO Ikosa-EPA for?

PURO Ikosa-EPA is designed for adults seeking a more focused omega-3 approach for heart health.

Heart health is your main priority

You prefer a highly purified, EPA-focused omega-3

You are managing cholesterol and cardiovascular disease, including with statins or other lipid-lowering medicines, and want to discuss EPA supplementation with your doctor or pharmacist.

When your priority is the heart, keep the focus on EPA.

  • A man in his fifties smiling on a morning walk in the park
  • A woman with glasses smiling up into the sunlight in a garden
  • A man talking with a pharmacist at a pharmacy counter
  • A man in a straw hat tending vegetables in a sunlit garden
  • A woman in her kitchen looking at a clear softgel, a glass of water beside her
  • An older couple laughing together on an outdoor walk
  • A man plating grilled salmon, vegetables and rice in his kitchen

Heart check

Not sure if this describes you?

Answer 7 quick questions about your heart health. It takes about a minute, and your answers stay on your device.

Quality

Quality begins with what goes inside.

A clear softgel held in steel tweezers over a glass dish
Japan Quality

Japanese Quality Standards

Developed to Nikko Pharma’s Japanese quality standards, with a strong emphasis on stringent quality control and manufacturing consistency.

GMP Certified, Good Manufacturing Practice

GMP Manufacturing

Manufactured under stringent GMP quality control in New Zealand.

Halal certified by the New Zealand Islamic Development Trust

Halal Certified

Halal certified

Product information

Product
PURO Ikosa-EPA
Form
Softgel
EPA per softgel
489 mg EPA Ethyl Ester
Fish oil per softgel
555.56 mg
Pack size
60 softgels (15 softgels × 4)
Recommended use
2 softgels once daily or 2 softgels twice daily
IFOS status
Omega-3 raw material is IFOS certified. Finished PURO Ikosa-EPA product is not separately IFOS certified.
Halal
Halal certified
Manufacturer
GMP Pharmaceuticals Ltd.
12 Averton Place, East Tamaki, Auckland, New Zealand.

Evidence

Why so much focus on EPA?

Two landmark trials. A clearer direction for heart health.

JELIS

18,645

patients

EPA added to statin therapy was associated with a 19% relative reduction in major coronary events versus statin therapy alone in the population studied.1

REDUCE-IT

8,179

patients

In statin-treated, high-risk patients with elevated triglycerides, icosapent ethyl was associated with a 25% relative reduction in the primary cardiovascular composite endpoint versus placebo.2

Want to understand why?

Explore the EPA science

Clinical studies referenced here evaluated specific EPA formulations, doses and patient populations and should not be interpreted as clinical trials of PURO Ikosa-EPA itself.

1. Yokoyama Mitsuhiro, Origasa Hideki, Matsuzaki Masunori, Matsuzawa Yuji, Saito Yasushi, Ishikawa Yuichi, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369(9567):1090-1098. doi:10.1016/S0140-6736(07)60527-3

2. Bhatt Deepak L, Steg P Gabriel, Miller Michael, Brinton Eliot A, Jacobson Terry A, Ketchum Steven B, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22. doi:10.1056/NEJMoa1812792

FAQ

Frequently asked questions

01What makes PURO Ikosa-EPA different from normal omega-3?

Most conventional omega-3 products contain a combination of EPA and DHA. PURO Ikosa-EPA is specifically focused on EPA, with DHA removed through further refinement.

Each softgel provides 489 mg EPA Ethyl Ester, giving Ikosa a higher EPA concentration in a compact softgel.

More importantly, purified EPA has the strongest cardiovascular outcomes evidence among omega-3 formulations studied in major clinical trials.

02Why is there no DHA in PURO Ikosa-EPA?

More isn’t always better.

Ikosa removes DHA through further refinement to keep the formulation focused on EPA. This approach follows the cardiovascular clinical evidence, where significant cardiovascular benefit has been demonstrated with purified EPA without DHA.

DHA removed by choice. Focused on EPA.

03Isn’t EPA + DHA better than EPA alone?

Not necessarily. More types of omega-3 do not automatically mean more cardiovascular benefit.

Major cardiovascular outcomes studies using purified EPA have demonstrated significant cardiovascular event reduction, while major studies using combined EPA + DHA have not consistently demonstrated the same benefit.

For heart health, purified EPA has the strongest cardiovascular outcomes evidence among omega-3 formulations studied.

That is why PURO Ikosa-EPA keeps the focus on EPA.

04What does “higher EPA concentration” mean, and why is the Ikosa softgel smaller?

EPA concentration refers to how much of the oil inside the softgel is actually EPA.

Each Ikosa softgel provides 489 mg EPA Ethyl Ester from 555.56 mg of fish oil. Its higher EPA concentration allows Ikosa to provide a focused amount of EPA in a more compact softgel.

Smaller softgel. Higher EPA concentration.

05Who should consider an EPA-focused omega-3?

PURO Ikosa-EPA is for adults whose main priority is heart health and who want their omega-3 intake to focus specifically on EPA.

Conventional EPA + DHA omega-3 products are generally positioned for broader nutritional support, including the nutritional roles of DHA for areas such as the brain and eyes.

Ikosa has a more specific purpose: when your priority is the heart, keep the focus on EPA.

06How many PURO Ikosa-EPA softgels should I take?

Take either 2 softgels once daily, or 2 softgels twice daily.

Each softgel provides 489 mg EPA Ethyl Ester.

If you have an existing medical condition or are taking prescription medicines, follow the advice of your doctor or pharmacist.

07Can I take PURO Ikosa-EPA together with another fish oil or omega-3 supplement?

We generally do not recommend adding another omega-3 product, particularly one containing DHA, when your purpose is heart health.

The cardiovascular outcomes evidence supporting purified EPA comes from EPA-focused formulations without DHA. If you add an EPA + DHA fish oil, the resulting combination is no longer the same formulation studied in those cardiovascular outcomes trials.

If you are already taking another omega-3 product, speak with your doctor or pharmacist before combining it with Ikosa.

08Can I take PURO Ikosa-EPA long term?

Yes. Heart health is a long-term commitment, and Ikosa is intended for regular daily use.

The major cardiovascular studies supporting purified EPA followed patients for several years, rather than using EPA only for a short period.

For ongoing heart-health support, consistency matters more than short-term use.

If you are under medical treatment, continue to review your supplements with your doctor or pharmacist.

09Will PURO Ikosa-EPA cause fishy burps?

Fishy aftertaste can occur with fish-oil products, but Ikosa uses a highly concentrated EPA formulation in a smaller softgel, meaning less total oil needs to be consumed compared with some conventional lower-concentration fish-oil formulations.

For this reason, fishy aftertaste may be less noticeable for some people.

However, taking several softgels together — for example, 4 softgels at one time — may increase the chance of a slight fishy aftertaste or burp. Taking Ikosa according to the recommended dosing schedule rather than taking all softgels together may help.

10Is PURO Ikosa-EPA IFOS certified?

PURO Ikosa-EPA as a finished product is not separately IFOS certified.

However, the omega-3 raw material used to manufacture Ikosa is IFOS certified, providing independent quality testing of the omega-3 ingredient used in the product.

Contact

Not all omega-3 is the same.

Know what you’re taking. Know why you’re taking it.

PURO Ikosa-EPA — Purified EPA. Cardiovascular-Focused by Design.